Aronia Extract, Powder & Concentrate

• Gerlib et al. (2002) – Aronia treatment showed increased flow-mediated dilation of the brachial artery in human subjects.
• Bell et al. (2006) – Compared to all berry extracts tested, aronia provided the best cellular protection from oxidative injury and had a direct vasorelaxation effect on the arterial endothelium through the stimulation of nitric oxide (NO).
• Naruszewicz et al. (2007) – Human pilot clinical trial where patients with myocardial infarction were treated with aronia. The study reported that aronia intake reduced systolic and diastolic blood pressure as well as other cardiovascular risk markers like C-reactive protein in these patients.
• Valcheva Kuzmanova et al. (2007) – In vivo study showed that an aronia juice treatment significantly hindered the elevation of plasma total cholesterol, LDL cholesterol and triglycerides in rats fed a high cholesterol diet.
• Poreba et al. (2009) – Concluded that regular intake of aronia juice had a beneficial effect on endothelial function and lipid metabolism in men with mild hypercholesterolemia. During the study, significant decreases in serum total cholesterol, LDL cholesterol and triglyceride levels were observed.
• Hawkins et al. (2020) – A meta-analysis analyzed all of the relevant human clinical trials to date and concluded that daily supplementation with aronia berry extracts for 6-8 weeks significantly reduces systolic blood pressure as well as total cholesterol. These effects were most significant in adults over the age of 50 years.

Several initial studies have indicated the role of aronia in supporting healthy glucose metabolism.

• Pawlowicz et al. (2000) – Aronia helped to normalize carbohydrate metabolism in insulin-dependent diabetic pregnant women.
• Simeonov et al. (2002) – Human study showed aronia was effective in lowering fasting blood glucose levels and had a beneficial effect on HbA1c, total cholesterol and lipid levels. Similar results were observed in animal models of diabetes.
• Valcheva Kuzmanova et al. (2007) – Aronia significantly reduced plasma glucose and triglycerides to levels that did not significantly differ from those of the normal control rats.
• Jurgónski et al. (2008) – In vivo study demonstrated aronia extract treatment ameliorated parameters of induced oxidative stress, glucose intolerance and hyperlipidemia.

Several initial studies have indicated the role of aronia in supporting gastric health.

• Jankowska et al. (1999) – Anthocyanins derived from aronia suppressed pancreatic edema in rats with pancreatitis and suppressed free radicals by inhibiting lipid peroxidation and inactivating adenosine deaminase.
• Matsumoto et al. (2004) – Aronia anthocyanins exhibited a significant protective effect on gastric mucosa in a dose-dependent manner in an animal model of gastric injury.
• Valcheva-Kuzmanova et al. (2005) – A pretreatment of aronia juice diminished the number and area of indomethacin-induced gastric lesions in rats. Histopathological examination demonstrated that the aronia induced an increase in gastric mucus production, further contributing to its gastroprotective effect. This same group of researchers reported hepatoprotective effects of aronia as well in 2006.

Berry anthocyanins have long been recognized as potent antioxidants and therefore help to promote healthy aging and overall cellular health.

• Rooprai et al. (2003) – Aronia extract introduced to highly malignant brain tumor cell lines down-regulated expression of CD44 and various matrix metalloproteinases, and promoted apoptosis within 24 hours. When combined with other botanical ingredients, aronia helped to affect pathways underlying diffuse invasion by invasive brain gliomas.
• Malik et al. (2003) – Aronia extract inhibited colon cancer cell growth without harming normal colon cells in vitro.
• In independent in vitro studies at University of Maryland, Cornell, and Purdue, aronia showed significant apoptosis in various cancer cell lines.

Studies have indicated the impact of aronia on markers of immune support and inflammation modulation.

• Ohgami et al. (2005) – Aronia extract had a dose-dependent anti-ocular inflammatory effect in an animal study that was attributed to the direct blocking of the expression of the iNOS and COX-2 enzymes and leads to the suppression of the production of NO, PGE2, and TNF-alpha.
• Preliminary in vitro studies also report antiviral and antimicrobial implications for aronia.